Amylopectinosis of the fatal epilepsy Lafora disease resists autophagic glycogen catabolism

In this Correspondence, B. Minassian and colleagues report that GHF201, an autophagy activator shown to diminish abnormal glycogen aggregates in a mouse model of Adult Polyglucosan Body Disease, fails to reduce such accumulations in a mouse model of Lafora disease.

Bibliographic Details
Main Authors: Jun Wu, Or Kakhlon, Miguel Weil, Alexander Lossos, Berge A Minassian
Format: Article
Language:English
Published: Springer Nature 2024-04-01
Series:EMBO Molecular Medicine
Online Access:https://doi.org/10.1038/s44321-024-00063-9