UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease

UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease

Abstract Reactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both resu...

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Bibliographic Details
Main Authors: Xiao-Tang Yin, Alexis Hartman, Nadia Sirajuddin, Deepak Shukla, Anthony St. Leger, Tammie L. Keadle, Patrick M. Stuart
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-52597-0

Internet

https://doi.org/10.1038/s41598-024-52597-0

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