Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice

Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice

Abstract Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant because cortical CHRM2 acts as an au...

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Bibliographic Details
Main Authors: Masayo Fujita, Yukiko Ochiai, Yoko Hagino, Kazuto Kobayashi, Geoffrey Pavey, Brian Dean, Kazutaka Ikeda
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Brain
Subjects:
Dopamine deficient
Muscarinic signaling
Muscarinic receptor
Binding assay
Hyperactivity
Online Access:https://doi.org/10.1186/s13041-022-00984-x

Internet

https://doi.org/10.1186/s13041-022-00984-x

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