A redox-responsive dihydroartemisinin dimeric nanoprodrug for enhanced antitumor activity

A redox-responsive dihydroartemisinin dimeric nanoprodrug for enhanced antitumor activity

Abstract Redox-responsive drug delivery system emerges as a hopeful platform for tumor treatment. Dihydroartemisinin (DHA) has been investigated as an innovative tumor therapeutic agent. Herein, a DHA dimeric prodrug bridged with disulfide bond as linker (DHA2-SS) has been designed and synthesized....

Full description

Bibliographic Details
Main Authors: Yawei Li, Qing Pei, Baiji Cui, Hongmei Zhang, Liu Han, Wenqing Li, Wenhe Zhu, Xianmin Feng, Zhigang Xie
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Journal of Nanobiotechnology
Subjects:
Dimeric nanoprodrug
Dihydroartemisinin
Redox-responsive
Antitumor activity
PI3K/AKT/HIF-1α signaling pathway
Online Access:https://doi.org/10.1186/s12951-021-01200-z

Internet

https://doi.org/10.1186/s12951-021-01200-z

Similar Items