A redox-responsive dihydroartemisinin dimeric nanoprodrug for enhanced antitumor activity

A redox-responsive dihydroartemisinin dimeric nanoprodrug for enhanced antitumor activity

Abstract Redox-responsive drug delivery system emerges as a hopeful platform for tumor treatment. Dihydroartemisinin (DHA) has been investigated as an innovative tumor therapeutic agent. Herein, a DHA dimeric prodrug bridged with disulfide bond as linker (DHA2-SS) has been designed and synthesized....

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Bibliographic Details
Main Authors:	Yawei Li, Qing Pei, Baiji Cui, Hongmei Zhang, Liu Han, Wenqing Li, Wenhe Zhu, Xianmin Feng, Zhigang Xie
Format:	Article
Language:	English
Published:	BMC 2021-12-01
Series:	Journal of Nanobiotechnology
Subjects:	Dimeric nanoprodrug Dihydroartemisinin Redox-responsive Antitumor activity PI3K/AKT/HIF-1α signaling pathway
Online Access:	https://doi.org/10.1186/s12951-021-01200-z

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