Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance

Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance

Summary: The interrelation between hypoxia and immune response has pivotal roles in the pathogenesis of chronic metabolic diseases. However, the role of macrophage HIF-2α in NLRP3 inflammasome activation remains unclear. Here, we show that deficiency of HIF-2α in macrophages results in excessive act...

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Bibliographic Details
Main Authors: Xiaopeng Li, Xiujuan Zhang, Jialin Xia, Linqi Zhang, Bo Chen, Guan Lian, Chuyu Yun, Juan Yang, Yu Yan, Pengcheng Wang, Xuemei Wang, Bo Liu, Huiying Liu, Hui Liang, Yanli Pang, Xian Wang, Changtao Jiang
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
macrophage
hypoxia inducible factor 2
EPAS1
FG-4592
Cpt1a
fatty acid oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010457

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http://www.sciencedirect.com/science/article/pii/S2211124721010457

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