Fusion of the β2‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

Fusion of the β2‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathwa...

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Bibliographic Details
Main Authors: Emilio Y. Lucero‐Garcia Rojas, Arfaxad Reyes‐Alcaraz, Kehe Ruan, Bradley K. McConnell, Richard A. Bond
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:FASEB BioAdvances
Subjects:
biased signaling
cytokine profile
Gαs protein
β arrestin 2
β2 adrenergic receptor
Online Access:https://doi.org/10.1096/fba.2022-00038

Internet

https://doi.org/10.1096/fba.2022-00038

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