TWEAK/Fn14 signaling may function as a reactive compensatory mechanism against extracellular matrix accumulation in keloid fibroblasts

TWEAK/Fn14 signaling may function as a reactive compensatory mechanism against extracellular matrix accumulation in keloid fibroblasts

Overabundance of the extracellular matrix resulting from hyperproliferation of keloid fibroblasts (KFs) and dysregulation of apoptosis represents the main pathophysiology underlying keloids. TWEAK is a weak apoptosis inducer, and it plays a critical role in pathological tissue remodeling via its rec...

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Bibliographic Details
Main Authors: Yitian Zhang, Xiaoli Li, Wei Liu, Guanglei Hu, Hanjiang Gu, Xiao Cui, Dewu Zhang, Weihui Zeng, Yumin Xia
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:European Journal of Cell Biology
Subjects:
α-SMA
Extracellular matrix
Fibroblast
Fn14
Keloid
TGF-β1
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933523000055

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http://www.sciencedirect.com/science/article/pii/S0171933523000055

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