Safety, pharmacokinetics, and pharmacodynamics in healthy Chinese volunteers treated with SC0062, a highly selective endothelin‐A receptor antagonist

Safety, pharmacokinetics, and pharmacodynamics in healthy Chinese volunteers treated with SC0062, a highly selective endothelin‐A receptor antagonist

Abstract This study evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and food effects (FE) of SC0062, a highly active endothelin‐A (ETA) receptor antagonist, in healthy subjects. The primary objectives of this first‐in‐human phase I study, comprised of single‐ascendi...

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Bibliographic Details
Main Authors: Yun Liu, Wei Wang, Hongjie Qian, Yuzhou Gui, Yating Wang, Rong Song, Qian Chen, Eric Rowinsky, Sheng Wang, Xiaoguang Liang, Kaicun Gu, Bo Zhou, Weiwei Zhang, Liqin Zhang, Chen Yu, Jingying Jia
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13750

Internet

https://doi.org/10.1111/cts.13750

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