Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence

Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence

Abstract Background Chemotherapeutic drugs, particularly alkylating cytotoxics such as cyclophosphamide (CTX), play an important role to induce premature ovarian failure (POF). Hormone replacement therapy (HRT) is a widely used treatment to improve hormone secretion. However, the long-term HRT incre...

Full description

Bibliographic Details
Main Authors: Guihai Ai, Meng Meng, Jing Guo, Caixia Li, Jihui Zhu, Li Liu, Biting Liu, Wenhan Yang, Xiaowen Shao, Zhongping Cheng, Lian Wang
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Stem Cell Research & Therapy
Subjects:
Premature ovarian failure
Adipose-derived stem cells
Microenvironment
Cellular senescence
PI3K/Akt/mTOR axis
Online Access:https://doi.org/10.1186/s13287-023-03297-5

Internet

https://doi.org/10.1186/s13287-023-03297-5

Similar Items