Mechanical Cues, E-Cadherin Expression and Cell “Sociality” Are Crucial Crossroads in Determining Pancreatic Ductal Adenocarcinoma Cells Behavior

Mechanical Cues, E-Cadherin Expression and Cell “Sociality” Are Crucial Crossroads in Determining Pancreatic Ductal Adenocarcinoma Cells Behavior

E-cadherin, an epithelial-to-mesenchymal transition (EMT) marker, is coupled to actin cytoskeleton and distributes cell forces acting on cells. Since YAP transduces mechanical signals involving actin cytoskeleton, we aimed to investigate the relationship between YAP and mechanical cues in pancreatic...

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Bibliographic Details
Main Authors: Francesca Bianchi, Michele Sommariva, Laura Brigida Cornaghi, Luca Denti, Ambra Nava, Francesca Arnaboldi, Claudia Moscheni, Nicoletta Gagliano
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
pancreatic cancer
3D spheroids
actin cytoskeleton
E-cadherin
epithelial-to-mesenchymal transition
MMPs
Online Access:https://www.mdpi.com/2073-4409/11/8/1318

Internet

https://www.mdpi.com/2073-4409/11/8/1318

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