Mitochondrial metabolism blockade nanoadjuvant reversed immune-resistance microenvironment to sensitize albumin-bound paclitaxel-based chemo-immunotherapy

Mitochondrial metabolism blockade nanoadjuvant reversed immune-resistance microenvironment to sensitize albumin-bound paclitaxel-based chemo-immunotherapy

Currently, the efficacy of albumin-bound paclitaxel (PTX@Alb) is still limited due to the impaired PTX@Alb accumulation in tumors partly mediated by the dense collagen distribution. Meanwhile, acquired immune resistance always occurs due to the enhanced programmed cell death-ligand 1 (PD-L1) express...

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Bibliographic Details
Main Authors: Zaigang Zhou, Wenjuan Luo, Chunjuan Zheng, Haoxiang Wang, Rui Hu, Hui Deng, Jianliang Shen
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Chemo-immunotherapy
Collagen
Transforming growth factor-β
Mitochondrial metabolism
Programmed cell death-ligand 1
Drug accumulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524002247

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http://www.sciencedirect.com/science/article/pii/S2211383524002247

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