Molecular dynamics simulation‐guided toehold mediated strand displacement probe for single‐nucleotide variants detection

Molecular dynamics simulation‐guided toehold mediated strand displacement probe for single‐nucleotide variants detection

Abstract Single nucleotide variant (SNV) has become an emerging biomarker for various diseases such as cancers and infectious diseases. Toehold‐mediated strand displacement (TMSD), the core reaction of DNA nanotechnology, has been widely leveraged to identify SNVs. However, inappropriate choice of m...

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Bibliographic Details
Main Authors: Linghao Zhang, Jing Chen, Mengya He, Xin Su
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Exploration
Subjects:
dynamic DNA nanotechnology
molecular dynamic simulation
oxDNA
SARS‐CoV‐2
single‐nucleotide variants
toehold mediated strand displacement
Online Access:https://doi.org/10.1002/EXP.20210265

Internet

https://doi.org/10.1002/EXP.20210265

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