A lipid off-switch for mTORC1
Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism, cell growth and survival. Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kβ (PI3KC2β) represses mTORC1 identifies PI3KC2β as a pharma...
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| Format: | Artikel |
| Sprache: | English |
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Taylor & Francis Group
2017-09-01
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| Schriftenreihe: | Molecular & Cellular Oncology |
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| Online Zugang: | http://dx.doi.org/10.1080/23723556.2017.1356899 |