A lipid off-switch for mTORC1
Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism, cell growth and survival. Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kβ (PI3KC2β) represses mTORC1 identifies PI3KC2β as a pharma...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-09-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1356899 |
| _version_ | 1797677182038835200 |
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| author | Alexander Wallroth Volker Haucke |
| author_facet | Alexander Wallroth Volker Haucke |
| author_sort | Alexander Wallroth |
| collection | DOAJ |
| description | Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism, cell growth and survival. Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kβ (PI3KC2β) represses mTORC1 identifies PI3KC2β as a pharmacological target for the treatment of diabetes and cancer. |
| first_indexed | 2024-03-11T22:41:20Z |
| format | Article |
| id | doaj.art-f2051a966f3f43ee936a12f00435d653 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:20Z |
| publishDate | 2017-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-f2051a966f3f43ee936a12f00435d6532023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-09-014510.1080/23723556.2017.13568991356899A lipid off-switch for mTORC1Alexander Wallroth0Volker Haucke1Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism, cell growth and survival. Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kβ (PI3KC2β) represses mTORC1 identifies PI3KC2β as a pharmacological target for the treatment of diabetes and cancer.http://dx.doi.org/10.1080/23723556.2017.1356899nutrient signalingmtorc1phosphoinositideslate endosomes/ lysosomesclass ii pi 3-kinasediabetescancer |
| spellingShingle | Alexander Wallroth Volker Haucke A lipid off-switch for mTORC1 Molecular & Cellular Oncology nutrient signaling mtorc1 phosphoinositides late endosomes/ lysosomes class ii pi 3-kinase diabetes cancer |
| title | A lipid off-switch for mTORC1 |
| title_full | A lipid off-switch for mTORC1 |
| title_fullStr | A lipid off-switch for mTORC1 |
| title_full_unstemmed | A lipid off-switch for mTORC1 |
| title_short | A lipid off-switch for mTORC1 |
| title_sort | lipid off switch for mtorc1 |
| topic | nutrient signaling mtorc1 phosphoinositides late endosomes/ lysosomes class ii pi 3-kinase diabetes cancer |
| url | http://dx.doi.org/10.1080/23723556.2017.1356899 |
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