A lipid off-switch for mTORC1

A lipid off-switch for mTORC1

Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism, cell growth and survival. Our finding that local phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis at late endosomes/ lysosomes by class II PI3Kβ (PI3KC2β) represses mTORC1 identifies PI3KC2β as a pharma...

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Bibliographic Details
Main Authors: Alexander Wallroth, Volker Haucke
Format: Article
Language:English
Published: Taylor & Francis Group 2017-09-01
Series:Molecular & Cellular Oncology
Subjects:
nutrient signaling
mtorc1
phosphoinositides
late endosomes/ lysosomes
class ii pi 3-kinase
diabetes
cancer
Online Access:http://dx.doi.org/10.1080/23723556.2017.1356899

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