PHLPP1 deficiency protects against age‐related intervertebral disc degeneration

PHLPP1 deficiency protects against age‐related intervertebral disc degeneration

Abstract Background Intervertebral disc (IVD) degeneration is strongly associated with low back pain and is highly prevalent in the elderly population. Hallmarks of IVD degeneration include cell loss and extracellular matrix degradation. The PH domain leucine‐rich‐repeats protein phosphatase (PHLPP1...

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Bibliographic Details
Main Authors: Changli Zhang, Katherine M. Joseph, Nazir M. Khan, Martha Elena Diaz‐Hernandez, Hicham Drissi, Svenja Illien‐Junger
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:JOR Spine
Subjects:
aging
FOXO1
intervertebral disc degeneration
matrix homeostasis
nucleus pulposus
PHLPP1
Online Access:https://doi.org/10.1002/jsp2.1224

Internet

https://doi.org/10.1002/jsp2.1224

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