Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line

Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line

In this study, we present the synthesis, kinetic studies of inhibitory activity toward aldo-keto reductase 1C (AKR1C) enzymes, and anticancer potential toward chemoresistant ovarian cancer of 10 organoruthenium compounds bearing diketonate (1–6) and hydroxyquinolinate (7–10) chelating ligands with t...

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Bibliographic Details
Main Authors: Jakob Kljun, Renata Pavlič, Eva Hafner, Tanja Lipec, Sara Moreno-Da Silva, Primož Tič, Iztok Turel, Tomaž Büdefeld, Jure Stojan, Tea Lanišnik Rižner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
ruthenium complexes
synthesis
crystal structure
anticancer
aldo-keto reductase
enzyme inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.920379/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.920379/full

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