GENERALIST: A latent space based generative model for protein sequence families.

Generative models of protein sequence families are an important tool in the repertoire of protein scientists and engineers alike. However, state-of-the-art generative approaches face inference, accuracy, and overfitting- related obstacles when modeling moderately sized to large proteins and/or prote...

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Bibliographic Details
Main Authors: Hoda Akl, Brooke Emison, Xiaochuan Zhao, Arup Mondal, Alberto Perez, Purushottam D Dixit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-11-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1011655