Effect of specific silencing HIF-1α on expression of Vimentin in OCM-1 cells under hypoxia

Effect of specific silencing HIF-1α on expression of Vimentin in OCM-1 cells under hypoxia

AIM:To investigate the effect of specific silencing hypoxia inducible factor-1 alpha(HIF-1α)by small interference RNA(siRNA)on expression of vimentin in human uveal melanoma cell lines(OCM-1)under hypoxia, in order to discuss the role of HIF-1α on epithelial-mesenchymal transition(EMT)in uveal melan...

Full description

Bibliographic Details
Main Authors:	Juan Zhao, Zhan-Yu Zhou, Shuang Wang, Fu-Xiang Yuan, Fa-Yan Lu
Format:	Article
Language:	English
Published:	Press of International Journal of Ophthalmology (IJO PRESS) 2014-03-01
Series:	Guoji Yanke Zazhi
Subjects:	uveal melanoma hypoxia-inducible factor-1 alpha Vimentin epithelial-mesenchymal transition RNA interference
Online Access:	http://www.ies.net.cn/cn_publish/2014/3/201403008.pdf

Similar Items

Effect of silencing HIF-1α by siRNA on the expression of erythropoietin in malignant melanoma of the choroid cell under hypoxia
by: Fu-Xiang Yuan, et al.
Published: (2015-07-01)

siRNA-induced silencing of hypoxia-inducible factor 3α (HIF3α) increases endurance capacity in rats
by: S Drozdovska, et al.
Published: (2016-04-01)

RNA Silencing in the Phytopathogenic Fungus Magnaporthe oryzae
by: Naoki Kadotani, et al.
Published: (2003-09-01)

Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease
by: Shi Yong Neo, et al.
Published: (2024-01-01)

Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines
by: Martowicz Agnieszka, et al.
Published: (2012-10-01)

High vimentin expression with E-cadherin expression loss predicts a poor prognosis after resection of grade 1 and 2 pancreatic neuroendocrine tumors
by: Bo Zhou, et al.
Published: (2021-03-01)

SETDB1 Overexpression Sets an Intertumoral Transcriptomic Divergence in Non-small Cell Lung Carcinoma
by: Yong-Kook Kang, et al.
Published: (2020-12-01)

PRRX1 Is a Novel Prognostic Biomarker and Facilitates Tumor Progression Through Epithelial–Mesenchymal Transition in Uveal Melanoma
by: Zhishang Meng, et al.
Published: (2022-02-01)

Prognostic Value of Aquaporin-3, Vimentin and E-cadherin Expressions in Invasive Breast Carcinoma: An Immunohistochemical Study
by: Amany Attia, et al.
Published: (2020-10-01)

Characterization of miR-3099-mediated posttranscriptional of target genes regulation during neurogenesis in mice
by: Zainal Abidin, Shahidee
Published: (2019)

Effect of RNA interference with HIF-1α on the growth of pulmonary artery endothelial cells in broiler chickens
by: Wen Peng, et al.
Published: (2024-05-01)

Programmed Death–Ligand 1 and Vimentin: A Tandem Marker as Prognostic Factor in NSCLC
by: Julien Ancel, et al.
Published: (2019-09-01)

Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1)
by: Xiang-Yu Zhu, et al.
Published: (2012-01-01)

Significance of the levels of Twist and Vimentin proteins in oral squamous cell carcinoma
by: GAO Wenfeng, et al.
Published: (2018-10-01)

LINC01559 promotes lung adenocarcinoma metastasis by disrupting the ubiquitination of vimentin
by: Hao Feng, et al.
Published: (2024-02-01)

SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats
by: Wei Huang, et al.
Published: (2021-06-01)

HIF-1α siRNA Leads to Apoptosis of Pancreatic Cancer Cells under Hypoxic Conditions
by: Chuangui CHEN, Jianqiu CHEN, Jinjin SUN
Published: (2009-02-01)

An aptamer and Au/Si CCA based SERS sensor for ultra-sensitive detection of Vimentin during EMT in gastric cancer
by: Lingling Cheng, et al.
Published: (2023-12-01)

Hypoxia-dependent drivers of melanoma progression
by: Simona D’Aguanno, et al.
Published: (2021-05-01)

RNAi-mediated gene silencing of lanosterol 14α- demethylase (ERG11)-encoding gene in ganoderma boninense
by: Lim, Fook Hwa
Published: (2022)

Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer
by: P. V. Tkachenko, et al.
Published: (2017-07-01)

Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer
by: P. V. Tkachenko, et al.
Published: (2017-07-01)

The Effect of Snail1 Gene Silencing by siRNA in Metastatic Breast Cancer Cell Lines
by: Mansoor ALETAHA, et al.
Published: (2017-05-01)

Vimentin Diversity in Health and Disease
by: Frida Danielsson, et al.
Published: (2018-09-01)

Strategies for Improving siRNA-Induced Gene Silencing Efficiency
by: Fatemeh Safari, et al.
Published: (2017-12-01)

MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators
by: Karen Aughton, et al.
Published: (2020-08-01)

Quercetin induces proteolysis of mesenchymal marker vimentin through activation of caspase-3, and decreases cancer stem cell population in human papillary thyroid cancer cell line.
by: Devavrat Tripathi, et al.
Published: (2021-11-01)

Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
by: Irene Ramos, et al.
Published: (2020-06-01)

α-Viniferin and ε-Viniferin Inhibited TGF-β1-Induced Epithelial-Mesenchymal Transition, Migration and Invasion in Lung Cancer Cells through Downregulation of Vimentin Expression
by: Wei-Chung Chiou, et al.
Published: (2022-05-01)

The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats
by: Kyeong Ho Ki, et al.
Published: (2010-12-01)

RNA silencing : methods and protocols /
by: Carmichael, Gordon G.
Published: (2005)

Dicer1 Promotes Colon Cancer Cell Invasion and Migration Through Modulation of tRF-20-MEJB5Y13 Expression Under Hypoxia
by: Na Luan, et al.
Published: (2021-03-01)

Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines
by: Dindyal Mandal, et al.
Published: (2023-02-01)

Long Non-Coding RNA GAS5 Targeting microRNA-21 to Suppress the Invasion and Epithelial–Mesenchymal Transition of Uveal Melanoma
by: Qi Y, et al.
Published: (2020-11-01)

Vimentin may reflect areas of pathologic involvement in biopsies from patients with autoimmune skin diseases
by: Ana Maria Abreu Velez, et al.
Published: (2014-04-01)

Detection of Anti-Vimentin Antibodies in Patients with Sarcoidosis
by: Anna Starshinova, et al.
Published: (2022-08-01)

A Multifunctional Nano-Delivery System Against Rheumatoid Arthritis by Combined Phototherapy, Hypoxia-Activated Chemotherapy, and RNA Interference
by: Li X, et al.
Published: (2022-12-01)

LncRNA HIF1A-AS2 promotes trophoblast invasion and epithelial-mesenchymal transformation by inhibiting miR-138-5p
by: LI Qin, et al.
Published: (2020-11-01)

Lentivirus-Mediated Silencing of Tiam1 Gene Influences Multiple Functions of a Human Colorectal Cancer Cell Line
by: Li Liu, et al.
Published: (2006-11-01)

siRNA Versus miRNA as Therapeutics for Gene Silencing
by: Jenny K W Lam, et al.
Published: (2015-01-01)