Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms

Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms

Traumatic brain injury induces potent inflammatory responses that can exacerbate secondary blood-brain barrier (BBB) disruption, neuronal injury, and neurological dysfunction. Dexmedetomidine is a novel α2-adrenergic receptor agonist that exert protective effects in various central nervous system di...

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Bibliographic Details
Main Authors: Dong Wang, Xin Xu, Yin-Gang Wu, Li Lyu, Zi-Wei Zhou, Jian-Ning Zhang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; traumatic brain injury; neuroinflammation; nuclear factor kappa B; NLRP3 inflammasome; brain edema; blood-brain barrier; tight junction proteins; apoptosis; neuroprotection; dexmedetomidine; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=5;spage=819;epage=826;aulast=Wang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=5;spage=819;epage=826;aulast=Wang

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