Endothelial NOX4 Oxidase Negatively Regulates Inflammation and Improves Morbidity During Influenza A Virus Lung Infection in Mice

Endothelial NOX4 Oxidase Negatively Regulates Inflammation and Improves Morbidity During Influenza A Virus Lung Infection in Mice

Endosomal NOX2 oxidase-dependent ROS production promotes influenza pathogenicity, but the role of NOX4 oxidase, which is highly expressed in the lung endothelium, is largely unknown. The aim of this study was to determine if endothelial NOX4 expression can influence viral pathology in vivo, using a...

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Bibliographic Details
Main Authors: Keshia S. Hendricks, Eunice E. To, Raymond Luong, Felicia Liong, Jonathan R. Erlich, Ajay M. Shah, Stella Liong, John J. O’Leary, Doug A. Brooks, Ross Vlahos, Stavros Selemidis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
influenza A virus
endothelial cell
oxidative stress
NADPH oxidase 4(NOX4)
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.883448/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.883448/full

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