Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer

Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer

Difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), has promising activity against various cancers and a tolerable safety profile for long-term use as a chemopreventive agent. However, the anti-tumor effects of DFMO in ovarian cancer cells have not been entire...

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Bibliographic Details
Main Authors: Woo Yeon Hwang, Wook Ha Park, Dong Hoon Suh, Kidong Kim, Yong Beom Kim, Jae Hong No
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
AP-1
apoptosis
DFMO
JNK
ovarian cancer
polyamines
Online Access:https://www.mdpi.com/1422-0067/22/19/10255

Internet

https://www.mdpi.com/1422-0067/22/19/10255

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