Sphingosine-1-Phosphate (S-1P) Promotes Differentiation of Naive Macrophages and Enhances Protective Immunity Against Mycobacterium tuberculosis

Sphingosine-1-Phosphate (S-1P) Promotes Differentiation of Naive Macrophages and Enhances Protective Immunity Against Mycobacterium tuberculosis

Sphingosine-1-phosphate (S-1P) is a key sphingolipid involved in the pathobiology of various respiratory diseases. We have previously demonstrated the significance of S-1P in controlling non-pathogenic mycobacterial infection in macrophages, and here we demonstrate the therapeutic potential of S-1P...

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Bibliographic Details
Main Authors: Vinod Nadella, Lalita Sharma, Pankaj Kumar, Pushpa Gupta, Umesh D. Gupta, Srikant Tripathi, Suresh Pothani, S. S. Y. H. Qadri, Hridayesh Prakash
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
sphingolipids
tuberculosis
S-1P receptors
macrophage polarization
innate immunity
lungs
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03085/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.03085/full

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