Misregulation of the IgH Locus in Thymocytes

Misregulation of the IgH Locus in Thymocytes

Functional antigen receptor genes are assembled by somatic rearrangements that are largely lymphocyte lineage specific. The immunoglobulin heavy chain (IgH) gene locus is unique amongst the seven antigen receptor loci in undergoing partial gene rearrangements in the wrong lineage. Here we demonstrat...

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Bibliographic Details
Main Authors: Gita Kumari, Tatiana Gerasimova, Hansen Du, Supriyo De, William H. Wood, Kevin G. Becker, Ranjan Sen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
VDJ recombination
IgH locus
thymocytes
enhancer
chromatin
B cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02426/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02426/full

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