The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition

The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition

Abstract Background The activation of the unfolded protein response (UPR) is closely linked to the pathogenesis of renal injuries. However, the role of XBP1, a crucial regulator of adaptive UPR, remains unclear during the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Met...

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Bibliographic Details
Main Authors: Jia-Huang Chen, Chia-Hsien Wu, Jia-Rong Jheng, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu, Chih-Kang Chiang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Biomedical Science
Subjects:
Unfolded protein response
XBP1
Fibrosis
Acute kidney injury
Chronic kidney disease
Online Access:https://doi.org/10.1186/s12929-022-00828-9

Internet

https://doi.org/10.1186/s12929-022-00828-9

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