MiR-181a Targets RSPO2 and Regulates Bone Morphogenetic Protein – WNT Signaling Crosstalk During Chondrogenic Differentiation of Mesenchymal Stromal Cells
Mechanisms of WNT and bone morphogenetic protein (BMP) signaling crosstalk is in the focus of multiple biological studies, and it also has been discovered to play important roles in human mesenchymal stromal cells (MSC) that are of great interest for neocartilage engineering due to their high chondr...
Main Authors: | Svitlana Melnik, Nina Hofmann, Jessica Gabler, Nicole Hecht, Wiltrud Richter |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-10-01
|
Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.747057/full |
Similar Items
-
RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunities
by: Ankit Srivastava, et al.
Published: (2024-03-01) -
MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1
by: Svitlana Melnik, et al.
Published: (2020-12-01) -
Decreased expression of GEM in osteoarthritis cartilage regulates chondrogenic differentiation via Wnt/β-catenin signaling
by: Lu Gan, et al.
Published: (2023-10-01) -
Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells
by: Svitlana Melnik, et al.
Published: (2019-03-01) -
Senescence during early differentiation reduced the chondrogenic differentiation capacity of mesenchymal progenitor cells
by: Chantal Voskamp, et al.
Published: (2023-08-01)