Buckwheat extracts rich in flavonoid aglycones and flavonoid glycosides significantly reduced blood glucose in diabetes mice
Plant flavonoids have various physiological functions beneficial to human health, but their content in plants is not high and usually exists in form of flavonoid glycosides with low bioavailability. This study used ultrasonic assisted ethanol extraction to extract flavonoids from common and tartary...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624000318 |
| _version_ | 1797311617376976896 |
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| author | Lu Shen Can Li Wanxia Wang Xiaoru Wang Dongqi Tang Fang Xiao Tao Xia |
| author_facet | Lu Shen Can Li Wanxia Wang Xiaoru Wang Dongqi Tang Fang Xiao Tao Xia |
| author_sort | Lu Shen |
| collection | DOAJ |
| description | Plant flavonoids have various physiological functions beneficial to human health, but their content in plants is not high and usually exists in form of flavonoid glycosides with low bioavailability. This study used ultrasonic assisted ethanol extraction to extract flavonoids from common and tartary buckwheat, the total flavonoid content increased significantly. After treated with β-glucosidase, flavonoid aglycones of common and tartary buckwheat increased by 27.51 % and 29.58 % respectively. Blood glucose of diabetic mice was significantly reduced by 38.20–47.20 % after receiving extracts for 4 weeks, of which tartary buckwheat extract treated with β-glucosidase had the best efficacy (47.20 %), which was 94.70 % of metformin hydrochloride group. The extracts could effectively restore serum and liver biochemical indicators and organ index, which may be related to regulating IRS-1/PI3K/AKT-1/mTOR and PI3K/AKT-1/GSK-3β signaling pathways. Our findings suggested that buckwheat extracts rich in flavonoid aglycones and glycosides could significantly improve hypoglycemic effect and alleviate insulin resistance in T2DM. |
| first_indexed | 2024-03-08T02:02:21Z |
| format | Article |
| id | doaj.art-f21a0d68d1794cf393bacb59590dd23f |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T02:02:21Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-f21a0d68d1794cf393bacb59590dd23f2024-02-14T05:14:32ZengElsevierJournal of Functional Foods1756-46462024-02-01113106029Buckwheat extracts rich in flavonoid aglycones and flavonoid glycosides significantly reduced blood glucose in diabetes miceLu Shen0Can Li1Wanxia Wang2Xiaoru Wang3Dongqi Tang4Fang Xiao5Tao Xia6School of Bioengineering, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR China; State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR ChinaSchool of Bioengineering, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR China; State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR ChinaSchool of Bioengineering, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR China; State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR ChinaSchool of Bioengineering, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR China; State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR ChinaCenter for Gene and Immunotherapy, Multidisciplinary Innovation Center for Nephrology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, PR ChinaDepartment of Cadres Medical Care and Gerontology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, PR China; Corresponding authors at: Department of Cadres Medical Care and Gerontology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, PR China (F. Xiao). School of Bioengineering, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR China (T. Xia).School of Bioengineering, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR China; State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR China; Corresponding authors at: Department of Cadres Medical Care and Gerontology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, PR China (F. Xiao). School of Bioengineering, Qilu University of Technology (Shandong Academy of Science), Jinan, Shandong 250353, PR China (T. Xia).Plant flavonoids have various physiological functions beneficial to human health, but their content in plants is not high and usually exists in form of flavonoid glycosides with low bioavailability. This study used ultrasonic assisted ethanol extraction to extract flavonoids from common and tartary buckwheat, the total flavonoid content increased significantly. After treated with β-glucosidase, flavonoid aglycones of common and tartary buckwheat increased by 27.51 % and 29.58 % respectively. Blood glucose of diabetic mice was significantly reduced by 38.20–47.20 % after receiving extracts for 4 weeks, of which tartary buckwheat extract treated with β-glucosidase had the best efficacy (47.20 %), which was 94.70 % of metformin hydrochloride group. The extracts could effectively restore serum and liver biochemical indicators and organ index, which may be related to regulating IRS-1/PI3K/AKT-1/mTOR and PI3K/AKT-1/GSK-3β signaling pathways. Our findings suggested that buckwheat extracts rich in flavonoid aglycones and glycosides could significantly improve hypoglycemic effect and alleviate insulin resistance in T2DM.http://www.sciencedirect.com/science/article/pii/S1756464624000318BuckwheatFlavonoid glycosidesFlavonoid aglyconesβ-Glucosidase, Hypoglycemic effectInsulin resistance |
| spellingShingle | Lu Shen Can Li Wanxia Wang Xiaoru Wang Dongqi Tang Fang Xiao Tao Xia Buckwheat extracts rich in flavonoid aglycones and flavonoid glycosides significantly reduced blood glucose in diabetes mice Journal of Functional Foods Buckwheat Flavonoid glycosides Flavonoid aglycones β-Glucosidase, Hypoglycemic effect Insulin resistance |
| title | Buckwheat extracts rich in flavonoid aglycones and flavonoid glycosides significantly reduced blood glucose in diabetes mice |
| title_full | Buckwheat extracts rich in flavonoid aglycones and flavonoid glycosides significantly reduced blood glucose in diabetes mice |
| title_fullStr | Buckwheat extracts rich in flavonoid aglycones and flavonoid glycosides significantly reduced blood glucose in diabetes mice |
| title_full_unstemmed | Buckwheat extracts rich in flavonoid aglycones and flavonoid glycosides significantly reduced blood glucose in diabetes mice |
| title_short | Buckwheat extracts rich in flavonoid aglycones and flavonoid glycosides significantly reduced blood glucose in diabetes mice |
| title_sort | buckwheat extracts rich in flavonoid aglycones and flavonoid glycosides significantly reduced blood glucose in diabetes mice |
| topic | Buckwheat Flavonoid glycosides Flavonoid aglycones β-Glucosidase, Hypoglycemic effect Insulin resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624000318 |
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