Reduced virulence of an extensively drug-resistant outbreak strain of Mycobacterium tuberculosis in a murine model.

Reduced virulence of an extensively drug-resistant outbreak strain of Mycobacterium tuberculosis in a murine model.

Bacterial drug resistance is often associated with a fitness cost. Large outbreaks of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB have been described that predominately affect persons with HIV infection. We obtained four closely-related Mycobacterium tuberculosis strains (genot...

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Bibliographic Details
Main Authors: Kristen L Jurcic Smith, Divey Saini, Svetoslav Bardarov, Michelle Larsen, Richard Frothingham, Neel R Gandhi, William R Jacobs, A Willem Sturm, Sunhee Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3986381?pdf=render

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http://europepmc.org/articles/PMC3986381?pdf=render

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