Protective Role of Perivascular Adipose Tissue in Endothelial Dysfunction and Insulin-Induced Vasodilatation of Hypercholesterolemic LDL Receptor-Deficient Mice

Protective Role of Perivascular Adipose Tissue in Endothelial Dysfunction and Insulin-Induced Vasodilatation of Hypercholesterolemic LDL Receptor-Deficient Mice

Background: Endothelial dysfunction plays a pivotal role in the initiation of atherosclerosis. Vascular insulin resistance might contribute to a reduction in endothelial nitric oxide (NO) production, leading to impaired endothelium-dependent relaxation in cardiometabolic diseases. Because perivascul...

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Bibliographic Details
Main Authors: Natali Baltieri, Daniele M. Guizoni, Jamaira A. Victorio, Ana P. Davel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Physiology
Subjects:
perivascular adipose tissue
endothelium
LDL receptor deficiency
hypercholesterolemia
nitric oxide
insulin
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00229/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00229/full

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