Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

<p>Abstract</p> <p>Background</p> <p>Proteolytic enzymes have been implicated in driving tumor progression by means of their cancer cell microenvironment activity where they promote proliferation, differentiation, apoptosis, migration, and invasion. Therapeutic strategi...

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Bibliographic Details
Main Authors: Kwok Hang Fai, Buick Richard J, Kuehn Diana, Gormley Julie A, Doherty Declan, Jaquin Thomas J, McClurg Angela, Ward Claire, Byrne Teresa, Jaworski Jacob, Leung Ka Lai, Snoddy Philip, McAnally Christine, Burden Roberta E, Gray Breena, Lowry Jenny, Sermadiras Isabelle, Gruszka Natalia, Courtenay-Luck Nigel, Kissenpfennig Adrien, Scott Christopher J, Johnston James A, Olwill Shane A
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Molecular Cancer
Subjects:
Cathepsin S
ADCC
antibody
protease
microenvironment
Online Access:http://www.molecular-cancer.com/content/10/1/147

Internet

http://www.molecular-cancer.com/content/10/1/147

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