Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes

Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes

Abstract Background Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate SMAD1/5 activation is required to maintain endothelial quiescence, excessive SMAD1/5 signaling promotes endothelial dysfunction...

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Bibliographic Details
Main Authors: Paul-Lennard Mendez, Leon Obendorf, Jerome Jatzlau, Wiktor Burdzinski, Maria Reichenbach, Vanasa Nageswaran, Arash Haghikia, Verena Stangl, Christian Hiepen, Petra Knaus
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Biology
Subjects:
Fluid shear stress
Endothelial cell
EndoMT
BMP
Endoglin
Caveolin
Online Access:https://doi.org/10.1186/s12915-022-01396-y

Internet

https://doi.org/10.1186/s12915-022-01396-y

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