IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice

IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice

Abstract Background The Zika virus (ZIKV) outbreak that occurred in multiple countries was linked to increased risk of nervous system injuries and congenital defects. However, host immunity- and immune-mediated pathogenesis in ZIKV infection are not well understood. Interleukin-22 (IL-22) is a cruci...

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Bibliographic Details
Main Authors: Yuejin Liang, Panpan Yi, Wenjuan Ru, Zuliang Jie, Hui Wang, Tamer Ghanayem, Xiaofang Wang, Edrous Alamer, Jinjun Liu, Haitao Hu, Lynn Soong, Jiyang Cai, Jiaren Sun
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
ZIKV
IL-22
Astrocytes
Brain
Microglia
Encephalitis
Online Access:http://link.springer.com/article/10.1186/s12974-020-01928-9

Internet

http://link.springer.com/article/10.1186/s12974-020-01928-9

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