Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer

Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer

Abstract Background Cancer-associated fibroblasts (CAFs) contribute notably to colorectal cancer (CRC) tumorigenesis, stiffness, angiogenesis, immunosuppression and metastasis, and could serve as a promising therapeutic target. Our purpose was to construct CAF-related prognostic signature for CRC. M...

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Bibliographic Details
Main Authors: Hang Zheng, Heshu Liu, Yang Ge, Xin Wang
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Cancer Cell International
Subjects:
Single-cell RNA-seq
Colorectal cancer
Cancer-associated fibroblasts
Tumor microenvironment
Prognosis
Online Access:https://doi.org/10.1186/s12935-021-02252-9

Internet

https://doi.org/10.1186/s12935-021-02252-9

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