Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease

Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease

Extracellular matrix (ECM) is an active player in cardiovascular calcification (CVC), a major public health issue with an unmet need for effective therapies. Lysyl oxidase (LOX) conditions ECM biomechanical properties; thus, we hypothesized that LOX might impact on mineral deposition in calcific aor...

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Bibliographic Details
Main Authors: Carme Ballester-Servera, Judith Alonso, Laia Cañes, Paula Vázquez-Sufuentes, Lídia Puertas-Umbert, Amaya Fernández-Celis, Manel Taurón, Antonio Rodríguez-Sinovas, Natalia López-Andrés, Cristina Rodríguez, José Martínez-González
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Lysyl oxidase
Cardiovascular calcification
Atherosclerosis
Extracellular matrix remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012672

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http://www.sciencedirect.com/science/article/pii/S0753332223012672

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