Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

Since the utilization of anthracyclines in cancer therapy, severe cardiotoxicity has become a major obstacle. The major challenge in treating cancer patients with anthracyclines is minimizing cardiotoxicity without compromising antitumor efficacy. Herein, histone deacetylase SIRT6 expression was red...

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Bibliographic Details
Main Authors: Kezheng Peng, Chenye Zeng, Yuqi Gao, Binliang Liu, Liyuan Li, Kang Xu, Yuemiao Yin, Ying Qiu, Mingkui Zhang, Fei Ma, Zhao Wang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
SIRT6
Doxorubicin
Cardiotoxicity
Antitumor efficacy
Ellagic acid
Mitochondrial homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001090

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http://www.sciencedirect.com/science/article/pii/S2211383523001090

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