Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

Since the utilization of anthracyclines in cancer therapy, severe cardiotoxicity has become a major obstacle. The major challenge in treating cancer patients with anthracyclines is minimizing cardiotoxicity without compromising antitumor efficacy. Herein, histone deacetylase SIRT6 expression was red...

Full description

Bibliographic Details
Main Authors: Kezheng Peng, Chenye Zeng, Yuqi Gao, Binliang Liu, Liyuan Li, Kang Xu, Yuemiao Yin, Ying Qiu, Mingkui Zhang, Fei Ma, Zhao Wang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
SIRT6
Doxorubicin
Cardiotoxicity
Antitumor efficacy
Ellagic acid
Mitochondrial homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001090

Similar Items

Similar Items