Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study
BackgroundKappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).ObjectiveTo investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB)....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1327947/full |
| _version_ | 1797386011018264576 |
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| author | Harald Hegen Klaus Berek Paola Cavalla Mikael Christiansen Andreja Emeršič Massimiliano Di Filippo Lorenzo Gaetani Michaela Hassler Cyra Leurs Dejan Milosavljevic Vincent van Pesch Thor Petersen Stefan Presslauer Igal Rosenstein Uroš Rot Uroš Rot Christine Schnabl Charlotte Teunissen Domizia Vecchio Marco Vercellino Florian Deisenhammer |
| author_facet | Harald Hegen Klaus Berek Paola Cavalla Mikael Christiansen Andreja Emeršič Massimiliano Di Filippo Lorenzo Gaetani Michaela Hassler Cyra Leurs Dejan Milosavljevic Vincent van Pesch Thor Petersen Stefan Presslauer Igal Rosenstein Uroš Rot Uroš Rot Christine Schnabl Charlotte Teunissen Domizia Vecchio Marco Vercellino Florian Deisenhammer |
| author_sort | Harald Hegen |
| collection | DOAJ |
| description | BackgroundKappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).ObjectiveTo investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB).MethodsPatients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation.ResultsA total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients.Conclusionκ-FLC index shows similar diagnostic sensitivity than OCB in PPMS. |
| first_indexed | 2024-03-08T22:03:46Z |
| format | Article |
| id | doaj.art-f2268023c7d1409780b691eaa832cee5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T22:03:46Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f2268023c7d1409780b691eaa832cee52023-12-19T10:48:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.13279471327947Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre studyHarald Hegen0Klaus Berek1Paola Cavalla2Mikael Christiansen3Andreja Emeršič4Massimiliano Di Filippo5Lorenzo Gaetani6Michaela Hassler7Cyra Leurs8Dejan Milosavljevic9Vincent van Pesch10Thor Petersen11Stefan Presslauer12Igal Rosenstein13Uroš Rot14Uroš Rot15Christine Schnabl16Charlotte Teunissen17Domizia Vecchio18Marco Vercellino19Florian Deisenhammer20Department of Neurology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Neurology, Medical University of Innsbruck, Innsbruck, AustriaMultiple Sclerosis Center and Neurologia I U, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, ItalyDepartment of Clinical Biochemistry, Regional Hospital in Horsens, Horsens, DenmarkDepartment of Neurology, University Medical Centre Ljubljana, Ljubljana, SloveniaSection of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, ItalySection of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, ItalyFH Campus Wien, University of Applied Sciences, Vienna, AustriaDepartment of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, Location VUMC, Amsterdam, NetherlandsFH Campus Wien, University of Applied Sciences, Vienna, AustriaCliniques Universitaires Saint-Luc, UCLouvain, Brussels, BelgiumSygehus Sønderjylland, Department of Regional Health Research, University Hospital of Southern Denmark, Hadersleben, Denmark0Department of Neurology, Klinikum Ottakring, Vienna, Austria1Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia2Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaFH Campus Wien, University of Applied Sciences, Vienna, Austria3Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam UMC, Location Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, Netherlands4Neurology Unit Department of Translational Medicine, Maggiore della Carità University Hospital, Novara, ItalyMultiple Sclerosis Center and Neurologia I U, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, ItalyDepartment of Neurology, Medical University of Innsbruck, Innsbruck, AustriaBackgroundKappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).ObjectiveTo investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB).MethodsPatients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation.ResultsA total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients.Conclusionκ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1327947/fullcerebrospinal fluidkappa free light chainprimary progressivemultiple sclerosisdiagnosissensitivity |
| spellingShingle | Harald Hegen Klaus Berek Paola Cavalla Mikael Christiansen Andreja Emeršič Massimiliano Di Filippo Lorenzo Gaetani Michaela Hassler Cyra Leurs Dejan Milosavljevic Vincent van Pesch Thor Petersen Stefan Presslauer Igal Rosenstein Uroš Rot Uroš Rot Christine Schnabl Charlotte Teunissen Domizia Vecchio Marco Vercellino Florian Deisenhammer Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study Frontiers in Immunology cerebrospinal fluid kappa free light chain primary progressive multiple sclerosis diagnosis sensitivity |
| title | Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study |
| title_full | Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study |
| title_fullStr | Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study |
| title_full_unstemmed | Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study |
| title_short | Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study |
| title_sort | diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis a multicentre study |
| topic | cerebrospinal fluid kappa free light chain primary progressive multiple sclerosis diagnosis sensitivity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1327947/full |
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