Comprehensive detection of genes causing a phenotype using phenotype sequencing and pathway analysis.

Discovering all the genetic causes of a phenotype is an important goal in functional genomics. We combine an experimental design for detecting independent genetic causes of a phenotype with a high-throughput sequencing analysis that maximizes sensitivity for comprehensively identifying them. Testing...

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Bibliographic Details
Main Authors: Marc Harper, Luisa Gronenberg, James Liao, Christopher Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3935835?pdf=render