Comprehensive detection of genes causing a phenotype using phenotype sequencing and pathway analysis.
Discovering all the genetic causes of a phenotype is an important goal in functional genomics. We combine an experimental design for detecting independent genetic causes of a phenotype with a high-throughput sequencing analysis that maximizes sensitivity for comprehensively identifying them. Testing...
Main Authors: | Marc Harper, Luisa Gronenberg, James Liao, Christopher Lee |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0088072&type=printable |
Similar Items
-
Comprehensive analysis of gene mutation and phenotype of tuberous sclerosis complex in China
by: Guo-qiang HUANG, et al.
Published: (2015-04-01) -
Biallelic variants in coenzyme Q10 biosynthesis pathway genes cause a retinitis pigmentosa phenotype
by: Neringa Jurkute, et al.
Published: (2022-10-01) -
Global gene disruption in human cells to assign genes to phenotypes by deep sequencing.
by: Carette, J, et al.
Published: (2011) -
Comprehensive analysis of two hotspot codons in the TUBB4B gene and associated phenotypes
by: Jan-Philipp Bodenbender, et al.
Published: (2024-05-01) -
A De Novo Whole GCK Gene Deletion Not Detected by Gene Sequencing, in a Boy with Phenotypic GCK Insufficiency
by: N. H. Birkebæk, et al.
Published: (2011-01-01)