Combinatorial and Machine Learning Approaches for Improved Somatic Variant Calling From Formalin-Fixed Paraffin-Embedded Genome Sequence Data

Combinatorial and Machine Learning Approaches for Improved Somatic Variant Calling From Formalin-Fixed Paraffin-Embedded Genome Sequence Data

Formalin fixation of paraffin-embedded tissue samples is a well-established method for preserving tissue and is routinely used in clinical settings. Although formalin-fixed, paraffin-embedded (FFPE) tissues are deemed crucial for research and clinical applications, the fixation process results in mo...

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Bibliographic Details
Main Authors: Dollina D. Dodani, Matthew H. Nguyen, Ryan D. Morin, Marco A. Marra, Richard D. Corbett
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Genetics
Subjects:
FFPE (formalin fixed paraffin-embedded)
whole genome
somatic variant calling
combinatorics
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.834764/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.834764/full

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