PROPERTY: study protocol for a randomized, double-blind, multicenter placebo-controlled trial assessing neurotoxicity in patients with metastatic gastrointestinal cancer taking PHYCOCARE® during oxaliplatin-based chemotherapy

PROPERTY: study protocol for a randomized, double-blind, multicenter placebo-controlled trial assessing neurotoxicity in patients with metastatic gastrointestinal cancer taking PHYCOCARE® during oxaliplatin-based chemotherapy

Abstract Background Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common adverse effects of antineoplastic agents, ranging in prevalence from 19% to over 85%. Clinically, CIPN is a predominantly sensory neuropathy that may be accompanied by motor and autonomic changes of varyi...

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Main Authors: Christele Le Gouill-Jaijarat, Yann Péréon, Maxime Leroy, Olivier Lépine, Aymeric Loloum, Claire Peluchon, Christelle Volteau, Anne-Sophie Martineau, Simon Korner, Caroline Perrault, Asmahane Benmaziane, Paul Girot, Caroline Petorin, Clément Perret, Catherine Ligeza-Poisson, Didier Mayeur, Laurent Flet, Anne Chiffoleau, Alexandra Poinas, Jaafar Bennouna
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Trials
Subjects:
Chemotherapy-induced peripheral neuropathy
Sensory neuropathy
Neurotoxicity
Spirulina extract
Phycocyanin
Oxaliplatin
Online Access:https://doi.org/10.1186/s13063-023-07071-z

Internet

https://doi.org/10.1186/s13063-023-07071-z

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