Discovery of novel DENN proteins: implications for the evolution of eukaryotic intracellular membrane structures and human disease

Discovery of novel DENN proteins: implications for the evolution of eukaryotic intracellular membrane structures and human disease

The tripartite DENN module, comprised of a N-terminal longin domain, followed by DENN and d-DENN domains, is a GDP-GTP exchange factor (GEFs) for Rab GTPases, which are regulators of practically all membrane trafficking events in eukaryotes. Using sequence and structure analysis we identify multiple...

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Bibliographic Details
Main Authors: Dapeng eZhang, Lakshminarayan M Iyer, Fang eHe, L eAravind
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Genetics
Subjects:
evolution
ALS
Membrane trafficking
C9orf72
homology detection
DENN domain
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00283/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00283/full

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