Five Days Granulocyte Colony-Stimulating Factor Treatment Increases Bone Formation and Reduces Gap Size of a Rat Segmental Bone Defect: A Pilot Study

Five Days Granulocyte Colony-Stimulating Factor Treatment Increases Bone Formation and Reduces Gap Size of a Rat Segmental Bone Defect: A Pilot Study

Bone is an organ with high natural regenerative capacity and most fractures heal spontaneously when appropriate fracture fixation is provided. However, additional treatment is required for patients with large segmental defects exceeding the endogenous healing potential and for patients suffering fro...

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Bibliographic Details
Main Authors: Marietta Herrmann, Stephan Zeiter, Ursula Eberli, Maria Hildebrand, Karin Camenisch, Ursula Menzel, Mauro Alini, Sophie Verrier, Vincent A. Stadelmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
critical size bone defect
fracture
bone regeneration
endothelial progenitor cells
vascularization
granulocyte colony-stimulating factor
Online Access:http://journal.frontiersin.org/article/10.3389/fbioe.2018.00005/full

Internet

http://journal.frontiersin.org/article/10.3389/fbioe.2018.00005/full

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