A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase

A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase

The maintenance of a proper NAD<sup>+</sup> pool is essential for cell survival, and tumor cells are particularly sensitive to changes in coenzyme levels. In this view, the inhibition of NAD<sup>+</sup> biosynthesis is considered a promising therapeutic approach. Current rese...

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Bibliographic Details
Main Authors: Gabriele Minazzato, Elisa Marangoni, Carlo Fortunato, Riccardo Petrelli, Loredana Cappellacci, Fabio Del Bello, Leonardo Sorci, Massimiliano Gasparrini, Francesco Piacente, Santina Bruzzone, Nadia Raffaelli
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
NAD<sup>+</sup> biosynthesis
NAPRT
enzyme activity assay
Online Access:https://www.mdpi.com/1420-3049/28/3/961

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https://www.mdpi.com/1420-3049/28/3/961

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