Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.
In response to DNA damage, the eukaryotic genome surveillance system activates a checkpoint kinase cascade. In the fission yeast Schizosaccharomyces pombe, checkpoint protein Crb2 is essential for DNA damage-induced activation of downstream effector kinase Chk1. The mechanism by which Crb2 mediates...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3390401?pdf=render |