Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.

Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.

In response to DNA damage, the eukaryotic genome surveillance system activates a checkpoint kinase cascade. In the fission yeast Schizosaccharomyces pombe, checkpoint protein Crb2 is essential for DNA damage-induced activation of downstream effector kinase Chk1. The mechanism by which Crb2 mediates...

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Bibliographic Details
Main Authors:	Meng Qu, Bing Yang, Li Tao, John R Yates, Paul Russell, Meng-Qiu Dong, Li-Lin Du
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-07-01
Series:	PLoS Genetics
Online Access:	http://europepmc.org/articles/PMC3390401?pdf=render

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