Arctigenin Attenuates Tumor Metastasis Through Inhibiting Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma via Suppressing GSK3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro

Arctigenin Attenuates Tumor Metastasis Through Inhibiting Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma via Suppressing GSK3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro

Arctigenin (ARG) has been reported to be a bioactive lignan from Arctium lappa exerting various activities including anti-cancer and immune-regulation. The present study aimed to investigate the anti-metastasis activity and mechanism of ARG against hepatocellular carcinoma in vitro and in vivo. The...

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Bibliographic Details
Main Authors: Zheng Lu, Lingling Chang, Hongbo Zhou, Xiaoqiang Liu, Yinqian Li, Tiejun Mi, Dewen Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
arctigenin
hepatocellular carcinoma
anti-metastasis
anti-epithelial – mesenchymal transition
Wnt/β-catenin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00937/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00937/full

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