An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging
Huntington’s disease is a dominantly inherited neurodegenerative disorder caused by the expansion of a CAG repeat, encoding for the amino acid glutamine (Q), present in the first exon of the protein huntingtin. Over the threshold of Q39 HTT exon 1 (HTTEx1) tends to misfold and aggregate into large i...
| Päätekijät: | , , , , |
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
| Julkaistu: |
Frontiers Media S.A.
2021-10-01
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| Sarja: | Frontiers in Molecular Neuroscience |
| Aiheet: | |
| Linkit: | https://www.frontiersin.org/articles/10.3389/fnmol.2021.721749/full |