Lymphatic Phenotype of Noonan Syndrome: Innovative Diagnosis and Possible Implications for Therapy

Lymphatic Phenotype of Noonan Syndrome: Innovative Diagnosis and Possible Implications for Therapy

Dysregulation of the Ras/Mitogen-activated protein kinase (MAPK) signaling pathway is suggested to play a pivotal role in the development of the lymphatic system in patients with Noonan Syndrome (NS). Pathogenic gene variants in the Ras/MAPK pathway can therefore lead to various lymphatic diseases s...

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Bibliographic Details
Main Authors: Lotte E. R. Kleimeier, Caroline van Schaik, Erika Leenders, Maxim Itkin, Willemijn M. Klein, Jos M. T. Draaisma
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Journal of Clinical Medicine
Subjects:
Noonan Syndrome
lymphatic disease
dynamic contrast-enhanced MR lymphangiography
central conducting lymphatic anomaly
Online Access:https://www.mdpi.com/2077-0383/11/11/3128

Internet

https://www.mdpi.com/2077-0383/11/11/3128

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